What is a transcription factor?
What is the role of transcription factor biding sites?
- Transcription factors (TFs) are the key regulators involved in transcriptional regulation . Most TFs recognize and bind to specific DNA sequences named as transcription factor biding sites (TFBSs), leading to specific spatiotemporal expression patterns of target genes .
What can we learn from large-scale omics datasets about transcription factor regulation?
- Therefore, integrating large-scale omics datasets for TFs (including TFBSs, target prediction, mRNA profiling, and epigenetic status of chromatin) can provide a comprehensive resource of TF–target regulations and benefit researchers in transcriptional regulation studies .
What is transcriptional regulation?
- Transcriptional regulation is a fundamental and vital process for general and condition-specific gene expression . Transcription factors (TFs) are the key regulators involved in transcriptional regulation .
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