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What is a transcription factor?

What is the role of transcription factor biding sites?

  • Transcription factors (TFs) are the key regulators involved in transcriptional regulation [2]. Most TFs recognize and bind to specific DNA sequences named as transcription factor biding sites (TFBSs), leading to specific spatiotemporal expression patterns of target genes [3].

What can we learn from large-scale omics datasets about transcription factor regulation?

  • Therefore, integrating large-scale omics datasets for TFs (including TFBSs, target prediction, mRNA profiling, and epigenetic status of chromatin) can provide a comprehensive resource of TF–target regulations and benefit researchers in transcriptional regulation studies [14].

What is transcriptional regulation?

  • Transcriptional regulation is a fundamental and vital process for general and condition-specific gene expression [1]. Transcription factors (TFs) are the key regulators involved in transcriptional regulation [2].

image-What is a transcription factor?
image-What is a transcription factor?
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